TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

In some tumours, despite a wild-type p53 gene, the p53 pathway is inactivated by alterations in its regulators or by unknown mechanisms, leading to resistance to cytotoxic therapies. Understanding the mechanisms of functional inactivation of wild-type p53 in these tumours may help to define prospective targets for treating cancer by restoring p53 activity. Recently, we identified TRIM8 as a new...

Renal cell carcinoma with proliferative lupus nephritis.

We report a case of renal cell carcinoma diagnosed after a patient was treated successfully with intravenous cyclophosphamide for her active proliferative lupus nephritis (classes III and V). After the intravenous cyclophosphamide regimen, the patient was asymptomatic with persistent microscopic haematuria, and no proteinuria. The renal cell carcinoma was located on the left kidney; incidentall...

Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines.

BACKGROUND The activation of nuclear factor-kappaB (NF-kappaB) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, on two metastatic human RCC cell lines, ACHN and SN12K1. METHODS RCC cell lines and normal cells were exposed to 25 or 50 microM of PDTC....

Aqueous Extract of Anticancer Drug CRUEL Capsules Exerts Anti-Proliferative Effects in Renal Cell Carcinoma Cells

Cancer is one of the most deadly diseases for the society and one of the most challenging diseases for the scientists all over the world to tackle with. Drugs and therapies available until now are still not effective enough for most of the cancer types and have side effects. People are, therefore looking towards traditional Ayurveda system of medicine to find out relatively safe and cost effect...

Sarcomatoid Transrormation of Chromophobe Renal Cell Carcinoma